Former Director, Center for Chronic Kidney Disease, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Clinical Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Cleve Clin J Med. 2017 Nov;84(11):855-862. doi: 10.3949/ccjm.84gr.17007.
Recent decades have seen great advances in the understanding of chronic kidney disease, spurred by standardizing disease definitions and large-scale patient surveillance. African Americans are disproportionately affected by the disease, and recently discovered genetic variants in APOL1 that protect against sleeping sickness in Africa provide an important explanation for the increased burden. Studies are now under way to determine if genetic testing of African American transplant donors and recipients is advisable.
近几十年来，随着疾病定义的标准化和大规模患者监测，人们对慢性肾脏病的认识有了很大的提高。非裔美国人受该疾病的影响不成比例，最近在 APOL1 中发现的可预防非洲昏睡病的遗传变异为增加的负担提供了一个重要的解释。目前正在进行研究，以确定对非裔美国移植供体和受者进行基因检测是否可取。
