二甲基亚砜处理的弗瑞德红白血病细胞变异株中的病毒产生与血红蛋白合成
Virus production and hemoglobin synthesis in variant lines of dimethyl sulfoxide-treated Friend erythroleukemia cells.
作者信息
Tsuei D, Haubenstock H, Revoltella R, Friend C
出版信息
J Virol. 1979 Jul;31(1):178-83. doi: 10.1128/JVI.31.1.178-183.1979.
Abstract
Variant Friend erythroleukemia cell clones were compared in regard to their response to dimethyl sulfoxide and in their abilities to synthesize virus and hemoglobin. Clear evidence was obtained that cellular growth is required for virus production. The effects of dimethyl sulfoxide on virus production were not observed in cell lines that were resistant to growth perturbation by the compound. Studies of cell variants that were defective in either hemoglobin or virus synthesis indicate that these activities are independently regulated.
摘要
对Friend红白血病细胞克隆变体在对二甲基亚砜的反应以及合成病毒和血红蛋白的能力方面进行了比较。获得了明确的证据，即病毒产生需要细胞生长。在对该化合物的生长干扰具有抗性的细胞系中未观察到二甲基亚砜对病毒产生的影响。对血红蛋白或病毒合成有缺陷的细胞变体的研究表明，这些活性是独立调节的。
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