Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK.
Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK.
Trends Cell Biol. 2018 Feb;28(2):143-156. doi: 10.1016/j.tcb.2017.10.002. Epub 2017 Nov 21.
The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counterparts. A wide variety of pathogenic bacteria have been investigated using zebrafish models, providing unprecedented resolution of the cellular response to infection in vivo. In this review, we illustrate how zebrafish models have contributed to our understanding of cellular microbiology by providing an in vivo platform to study host-pathogen interactions from the single cell to whole animal level. We also highlight discoveries made from zebrafish infection that hold great promise for translation into novel therapies for humans.
宿主-病原体相互作用的研究阐明了感染和细胞生物学两个领域的基础研究途径。斑马鱼（Danio rerio）幼虫具有遗传上的可操作性、光学可及性，并且具有完整的先天免疫系统，其中的巨噬细胞和中性粒细胞与哺乳动物的对应物相似。已经使用斑马鱼模型研究了多种致病性细菌，为体内感染细胞反应提供了前所未有的分辨率。在这篇综述中，我们通过提供从单细胞到整个动物水平研究宿主-病原体相互作用的体内平台，说明了斑马鱼模型如何帮助我们理解细胞微生物学。我们还强调了从斑马鱼感染中发现的具有巨大转化为人类新型疗法潜力的发现。
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