脑源性神经营养因子（BDNF）中的 RS 10767664 基因变异会影响标准低热量饮食后的代谢变化和胰岛素抵抗。
RS 10767664 gene variant in Brain Derived Neurotrophic Factor (BDNF) affect metabolic changes and insulin resistance after a standard hypocaloric diet.
机构信息
Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
出版信息
J Diabetes Complications. 2018 Feb;32(2):216-220. doi: 10.1016/j.jdiacomp.2017.10.005. Epub 2017 Oct 14.
BACKGROUND
Role of BDNF variants on change in body weight and cardiovascular risk factors after weight loss remains unclear in obese patients.
OBJECTIVE
Our aim was to analyze the effects of rs10767664 BDNF gene polymorphism on body weight, cardiovascular risk factors and serum adipokine levels after a standard hypocaloric diet in obese subjects.
DESIGN
A Caucasian population of 80 obese patients was analyzed before and after 3months on a standard hypocaloric diet.
RESULTS
Fifty patients (62.5%) had the genotype AA and 30 (37.5%) subjects had the next genotypes; AT (25 patients, 31.3%) or TT (5 study subjects, 6.3%) (second group). In non T allele carriers, the decreases in weight-3.4±2.9kg (T allele group -1.7±2.0kg:p=0.01), BMI -1.5±0.2kg (T allele group -1.2±0.5kg:p=0.02), fat mass-2.3±1.1kg (T allele group -1.7±0.9kg:p=0.009), waist circumference-3.8±2.4cm (T allele group -2.1±3.1cm:p=0.008), triglycerides -13.2±7.5mg/dl (T allele group +2.8±1.2mg/dl:p=0.02), insulin -2.1±1.9mUI/L (T allele group -0.3±1.0mUI/L:p=0.01), HOMA-IR -0.9±0.4 (T allele group -0.1±0.8:p=0.01) and leptin -10.1±9.5ng/dl (T allele group -3.1±0.2ng/dl:p=0.01) were higher than T allele carriers.
CONCLUSION
rs10767664 variant of BDNF gene modify anthropometric and biochemical changes after weight loss with a hypocaloric diet.
背景
BDNF 变体在肥胖患者减肥后体重和心血管危险因素变化中的作用尚不清楚。
目的
我们旨在分析 rs10767664BDNF 基因多态性在肥胖患者接受标准低热量饮食后对体重、心血管危险因素和血清脂肪因子水平的影响。
设计
分析了 80 名肥胖患者在接受标准低热量饮食 3 个月前后的情况。
结果
50 名患者（62.5%）为 AA 基因型，30 名（37.5%）患者为 AT（25 名，31.3%）或 TT（5 名，6.3%）（第二组）基因型。在非 T 等位基因携带者中，体重下降 3.4±2.9kg（T 等位基因组-1.7±2.0kg：p=0.01），BMI 下降 1.5±0.2kg（T 等位基因组-1.2±0.5kg：p=0.02），脂肪量下降 2.3±1.1kg（T 等位基因组-1.7±0.9kg：p=0.009），腰围下降 3.8±2.4cm（T 等位基因组-2.1±3.1cm：p=0.008），甘油三酯下降 13.2±7.5mg/dl（T 等位基因组+2.8±1.2mg/dl：p=0.02），胰岛素下降 2.1±1.9mUI/L（T 等位基因组-0.3±1.0mUI/L：p=0.01），HOMA-IR 下降 0.9±0.4（T 等位基因组-0.1±0.8：p=0.01），瘦素下降 10.1±9.5ng/dl（T 等位基因组-3.1±0.2ng/dl：p=0.01）。
结论
BDNF 基因 rs10767664 变异可改变低热量饮食减肥后的人体测量和生化变化。
Zotero 插件