（R，S）-氯胺酮和（2R，6R）-羟基去甲氯胺酮诱导的持续抗抑郁样效应中共同募集的神经传递 - Suppr

Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

作者信息

Pham Thu Ha, Defaix Céline, Xu Xiaoming, Deng Shi-Xian, Fabresse Nicolas, Alvarez Jean-Claude, Landry Donald W, Brachman Rebecca A, Denny Christine A, Gardier Alain M

机构信息

CESP/UMR-S 1178, Université Paris-Sud, Faculté de Pharmacie, INSERM, Université Paris-Saclay, Châtenay Malabry, France.

Department of Medicine, Columbia University, New York, New York; Organic Chemistry Collaborative Center, Department of Medicine, Columbia University, New York, New York.

出版信息

Biol Psychiatry. 2018 Jul 1;84(1):e3-e6. doi: 10.1016/j.biopsych.2017.10.020. Epub 2017 Oct 26.

DOI:10.1016/j.biopsych.2017.10.020

PMID:29174592

Abstract

摘要

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Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

Biol Psychiatry. 2018 Jul 1;84(1):e3-e6. doi: 10.1016/j.biopsych.2017.10.020. Epub 2017 Oct 26.

Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.

Int J Neuropsychopharmacol. 2018 Jan 1;21(1):84-88. doi: 10.1093/ijnp/pyx108.

What Are the Causes for Discrepancies of Antidepressant Actions of (2R,6R)-Hydroxynorketamine?

Biol Psychiatry. 2018 Jul 1;84(1):e7-e8. doi: 10.1016/j.biopsych.2017.12.007. Epub 2017 Dec 27.

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ()-hydroxynorketamine.

J Psychopharmacol. 2019 Jan;33(1):12-24. doi: 10.1177/0269881118812095. Epub 2018 Nov 29.

Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions.

Neuropharmacology. 2020 Jun 15;170:108068. doi: 10.1016/j.neuropharm.2020.108068. Epub 2020 Mar 25.

Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model.

Behav Brain Res. 2019 Aug 5;368:111904. doi: 10.1016/j.bbr.2019.111904. Epub 2019 Apr 11.

Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression.

Psychopharmacology (Berl). 2015 Dec;232(23):4325-35. doi: 10.1007/s00213-015-4062-3. Epub 2015 Sep 4.

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

Neuropharmacology. 2024 Nov 1;258:110065. doi: 10.1016/j.neuropharm.2024.110065. Epub 2024 Jul 14.

(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.

Br J Pharmacol. 2019 Jul;176(14):2573-2592. doi: 10.1111/bph.14683. Epub 2019 May 13.

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model.

Psychopharmacology (Berl). 2018 Nov;235(11):3177-3185. doi: 10.1007/s00213-018-5017-2. Epub 2018 Sep 13.

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Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

作者信息

Pham Thu Ha, Defaix Céline, Xu Xiaoming, Deng Shi-Xian, Fabresse Nicolas, Alvarez Jean-Claude, Landry Donald W, Brachman Rebecca A, Denny Christine A, Gardier Alain M

机构信息

CESP/UMR-S 1178, Université Paris-Sud, Faculté de Pharmacie, INSERM, Université Paris-Saclay, Châtenay Malabry, France.

Department of Medicine, Columbia University, New York, New York; Organic Chemistry Collaborative Center, Department of Medicine, Columbia University, New York, New York.

出版信息

Biol Psychiatry. 2018 Jul 1;84(1):e3-e6. doi: 10.1016/j.biopsych.2017.10.020. Epub 2017 Oct 26.

DOI:10.1016/j.biopsych.2017.10.020

PMID:29174592

Abstract

摘要

相似文献

Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

Biol Psychiatry. 2018 Jul 1;84(1):e3-e6. doi: 10.1016/j.biopsych.2017.10.020. Epub 2017 Oct 26.

Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.

Int J Neuropsychopharmacol. 2018 Jan 1;21(1):84-88. doi: 10.1093/ijnp/pyx108.

What Are the Causes for Discrepancies of Antidepressant Actions of (2R,6R)-Hydroxynorketamine?

Biol Psychiatry. 2018 Jul 1;84(1):e7-e8. doi: 10.1016/j.biopsych.2017.12.007. Epub 2017 Dec 27.

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ()-hydroxynorketamine.

J Psychopharmacol. 2019 Jan;33(1):12-24. doi: 10.1177/0269881118812095. Epub 2018 Nov 29.

Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions.

Neuropharmacology. 2020 Jun 15;170:108068. doi: 10.1016/j.neuropharm.2020.108068. Epub 2020 Mar 25.

Behav Brain Res. 2019 Aug 5;368:111904. doi: 10.1016/j.bbr.2019.111904. Epub 2019 Apr 11.

Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression.

Psychopharmacology (Berl). 2015 Dec;232(23):4325-35. doi: 10.1007/s00213-015-4062-3. Epub 2015 Sep 4.

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

Neuropharmacology. 2024 Nov 1;258:110065. doi: 10.1016/j.neuropharm.2024.110065. Epub 2024 Jul 14.

(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.

Br J Pharmacol. 2019 Jul;176(14):2573-2592. doi: 10.1111/bph.14683. Epub 2019 May 13.

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model.

Psychopharmacology (Berl). 2018 Nov;235(11):3177-3185. doi: 10.1007/s00213-018-5017-2. Epub 2018 Sep 13.

引用本文的文献

Psilocybin as Transformative Fast-Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms.

Fundam Clin Pharmacol. 2025 Aug;39(4):e70038. doi: 10.1111/fcp.70038.

Bioactive ketamine metabolite exerts in vivo neuroplastogenic effects to improve hippocampal function in a treatment-resistant depression model.

Cell Rep. 2025 Jun 24;44(6):115743. doi: 10.1016/j.celrep.2025.115743. Epub 2025 May 21.

Advancing past ketamine: emerging glutamatergic compounds for the treatment of depression.

Eur Arch Psychiatry Clin Neurosci. 2024 Aug 29. doi: 10.1007/s00406-024-01875-z.

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

Neuropharmacology. 2024 Nov 1;258:110065. doi: 10.1016/j.neuropharm.2024.110065. Epub 2024 Jul 14.

The -methyl-d-aspartate receptor hypothesis of ketamine's antidepressant action: evidence and controversies.

Philos Trans R Soc Lond B Biol Sci. 2024 Jul 29;379(1906):20230225. doi: 10.1098/rstb.2023.0225. Epub 2024 Jun 10.

Exploring the multifaceted potential of (R)-ketamine beyond antidepressant applications.

Front Pharmacol. 2024 Apr 11;15:1337749. doi: 10.3389/fphar.2024.1337749. eCollection 2024.

Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.

Transl Psychiatry. 2024 Jan 22;14(1):47. doi: 10.1038/s41398-024-02744-y.

Targeting metaplasticity mechanisms to promote sustained antidepressant actions.

Mol Psychiatry. 2024 Apr;29(4):1114-1127. doi: 10.1038/s41380-023-02397-1. Epub 2024 Jan 4.

Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion.

iScience. 2023 Nov 23;26(12):108527. doi: 10.1016/j.isci.2023.108527. eCollection 2023 Dec 15.

cAMP-dependent protein kinase signaling is required for ()-hydroxynorketamine to potentiate hippocampal glutamatergic transmission.

J Neurophysiol. 2024 Jan 1;131(1):64-74. doi: 10.1152/jn.00326.2023. Epub 2023 Dec 5.

Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

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Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

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