(2R,6R)-羟基去甲氯胺酮抗抑郁作用存在差异的原因有哪些？ - Suppr

What Are the Causes for Discrepancies of Antidepressant Actions of (2R,6R)-Hydroxynorketamine?

作者信息

Hashimoto Kenji, Shirayama Yukihiko

机构信息

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan; Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.

出版信息

Biol Psychiatry. 2018 Jul 1;84(1):e7-e8. doi: 10.1016/j.biopsych.2017.12.007. Epub 2017 Dec 27.

DOI:10.1016/j.biopsych.2017.12.007

PMID:29409592

Abstract

摘要

相似文献

What Are the Causes for Discrepancies of Antidepressant Actions of (2R,6R)-Hydroxynorketamine?(2R,6R)-羟基去甲氯胺酮抗抑郁作用存在差异的原因有哪些？

Biol Psychiatry. 2018 Jul 1;84(1):e7-e8. doi: 10.1016/j.biopsych.2017.12.007. Epub 2017 Dec 27.

Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.（2R,6R）-羟基去甲氯胺酮在大鼠习得性无助模型中缺乏抗抑郁作用：与（R）-氯胺酮的比较。

Int J Neuropsychopharmacol. 2018 Jan 1;21(1):84-88. doi: 10.1093/ijnp/pyx108.

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ()-hydroxynorketamine.（）-羟基去甲氯胺在小鼠、大鼠和犬体内的生物利用度和抗抑郁疗效。

J Psychopharmacol. 2019 Jan;33(1):12-24. doi: 10.1177/0269881118812095. Epub 2018 Nov 29.

Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.（R，S）-氯胺酮和（2R，6R）-羟基去甲氯胺酮诱导的持续抗抑郁样效应中共同募集的神经传递

Biol Psychiatry. 2018 Jul 1;84(1):e3-e6. doi: 10.1016/j.biopsych.2017.10.020. Epub 2017 Oct 26.

()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions.()-羟基去甲氯胺通过 mGlu 受体发挥抗抑郁作用。

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6441-6450. doi: 10.1073/pnas.1819540116. Epub 2019 Mar 13.

(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.（2R，6R）-羟基去甲氯胺通过作用于中脑导水管周围灰质来挽救慢性应激诱导的抑郁样行为。

Neuropharmacology. 2018 Sep 1;139:1-12. doi: 10.1016/j.neuropharm.2018.06.033. Epub 2018 Jun 25.

(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.(R)-氯胺酮通过转化为（2R,6R）-羟基去甲氯胺酮发挥抗抑郁作用，而在亚麻醉剂量下会引起不良反应。

Br J Pharmacol. 2019 Jul;176(14):2573-2592. doi: 10.1111/bph.14683. Epub 2019 May 13.

Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions.脑源性神经营养因子在腹外侧导水管周围灰质中有助于（2R,6R）-羟基去甲氯胺酮介导的作用。

Neuropharmacology. 2020 Jun 15;170:108068. doi: 10.1016/j.neuropharm.2020.108068. Epub 2020 Mar 25.

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression.AMPA 受体参与氯胺酮在抑郁动物模型中快速和持续的抗抑郁样作用。

Behav Brain Res. 2011 Oct 10;224(1):107-11. doi: 10.1016/j.bbr.2011.05.035. Epub 2011 Jun 6.

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model.（R）-氯胺酮在慢性社会挫败应激模型中抗抑郁作用中无氘同位素效应。

Psychopharmacology (Berl). 2018 Nov;235(11):3177-3185. doi: 10.1007/s00213-018-5017-2. Epub 2018 Sep 13.

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Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics?“神秘体验”对于氯胺酮和经典致幻剂的抗抑郁作用是否至关重要？

Eur Arch Psychiatry Clin Neurosci. 2024 Feb 27. doi: 10.1007/s00406-024-01770-7.

The effects of (2R,6R)-hydroxynorketamine on oxycodone withdrawal and reinstatement.(2R,6R)-羟基去甲氯胺酮对羟考酮戒断和复吸的影响。

Drug Alcohol Depend. 2023 Dec 1;253:110987. doi: 10.1016/j.drugalcdep.2023.110987. Epub 2023 Oct 5.

A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment.BDNF 在抑郁症及其治疗中的作用的文献计量学分析

Biomolecules. 2022 Oct 12;12(10):1464. doi: 10.3390/biom12101464.

Comments to behavioral tests for antidepressant-like actions of (2R,6R)-hydroxynorketamine by Bonaventura et al.博纳文图拉等人对(2R,6R)-羟基诺氯胺酮抗抑郁样作用行为测试的评论

Mol Psychiatry. 2024 Jan;29(1):3-4. doi: 10.1038/s41380-022-01766-6. Epub 2022 Sep 13.

Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search.（2R,6R）-羟基去甲凯他明的靶向去卷积研究：一场难以捉摸的探索。

Mol Psychiatry. 2022 Oct;27(10):4144-4156. doi: 10.1038/s41380-022-01673-w. Epub 2022 Jun 29.

Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor.亚胺培南抗抑郁作用的分子机制：超越 NMDA 受体。

Mol Psychiatry. 2022 Jan;27(1):559-573. doi: 10.1038/s41380-021-01121-1. Epub 2021 May 7.

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites.氯胺酮对映异构体及其代谢物抗抑郁作用的分子和细胞机制。

Transl Psychiatry. 2019 Nov 7;9(1):280. doi: 10.1038/s41398-019-0624-1.

Rodent ketamine depression-related research: Finding patterns in a literature of variability.啮齿动物氯胺酮抑郁相关研究：在变异性文献中寻找模式。

Behav Brain Res. 2019 Dec 30;376:112153. doi: 10.1016/j.bbr.2019.112153. Epub 2019 Aug 13.

Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.快速作用抗抑郁药氯胺酮及其代谢物和其他候选药物：历史概述和未来展望。

Psychiatry Clin Neurosci. 2019 Oct;73(10):613-627. doi: 10.1111/pcn.12902. Epub 2019 Jul 11.

Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test.氯胺酮在小鼠强迫游泳试验中的应激敏感抗抑郁样作用。

PLoS One. 2019 Apr 15;14(4):e0215554. doi: 10.1371/journal.pone.0215554. eCollection 2019.

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What Are the Causes for Discrepancies of Antidepressant Actions of (2R,6R)-Hydroxynorketamine?

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