基于 Centiloid 方法评价皮质下血管性痴呆的淀粉样 PET。
Centiloid method evaluation for amyloid PET of subcortical vascular dementia.
机构信息
Department of Biomedical Engineering, Hanyang University, Seoul, 04763, Korea.
Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, 02115, MA, USA.
出版信息
Sci Rep. 2017 Nov 24;7(1):16322. doi: 10.1038/s41598-017-16236-1.
Reference region selection is important for proper amyloid PET analysis, especially in subcortical vascular dementia (SVaD) patients. We investigated reference region differences between SVaD and Alzheimer's disease (AD) using Centiloid scores. In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM). We calculated disease group differences from young controls (YC) and YC variance according to reference region. SVaD patients showed large effect sizes (Cohen's d > 0.8) using all reference regions. WM and pons showed larger YC variances than other regions. Findings were similar for AD patients. CG, WC, and WC + B, but not WM or pons, are reliable reference regions for amyloid imaging analysis in SVaD.
参考区域的选择对于正确的淀粉样蛋白 PET 分析很重要，特别是在皮质下血管性痴呆（SVaD）患者中。我们使用 Centiloid 评分研究了 SVaD 和阿尔茨海默病（AD）之间参考区域的差异。在 57 名[C-11]匹兹堡化合物 B（PiB）阳性（+）AD 和 23 名 PiB（+）SVaD 患者中，我们评估了特定于疾病的皮质区域的标准化 PiB 摄取和 Centiloid 评分，使用了几个参考区域：小脑灰质（CG）、整个小脑（WC）、包括脑干的 WC（WC+B）、脑桥和白质（WM）。我们根据参考区域计算了 SVaD 患者与年轻对照组（YC）之间的疾病组差异和 YC 方差。使用所有参考区域，SVaD 患者的差异均具有较大的效应量（Cohen's d＞0.8）。WM 和脑桥的 YC 方差大于其他区域。AD 患者的结果相似。CG、WC 和 WC+B，但不是 WM 或脑桥，是 SVaD 淀粉样蛋白成像分析的可靠参考区域。
Zotero 插件