百分制项目：通过正电子发射断层扫描（PET）实现定量淀粉样斑块评估的标准化。
The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET.
作者信息
Klunk William E, Koeppe Robert A, Price Julie C, Benzinger Tammie L, Devous Michael D, Jagust William J, Johnson Keith A, Mathis Chester A, Minhas Davneet, Pontecorvo Michael J, Rowe Christopher C, Skovronsky Daniel M, Mintun Mark A
机构信息
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh. PA, USA.
Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Alzheimers Dement. 2015 Jan;11(1):1-15.e1-4. doi: 10.1016/j.jalz.2014.07.003. Epub 2014 Oct 28.
Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤ 45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.
尽管使用匹兹堡化合物B正电子发射断层扫描（PiB-PET，即[C-11]匹兹堡化合物B正电子发射断层扫描）以及现在使用F-18标记示踪剂进行的淀粉样蛋白成像，在大量研究中心已产生了非常一致的定性结果，但作为示踪剂保留定量结果指标所报告的确切数值却存在相当大的差异。在某些情况下，这就像单位选择一样微不足道；在某些情况下，这取决于扫描仪；当然，不同的示踪剂会得出不同的数值。我们的工作组旨在通过将每种特定分析方法或示踪剂的结果按比例换算到0至100的量表上，以年轻对照者（≤45岁）和典型阿尔茨海默病患者为基准，来规范淀粉样蛋白成像的定量测量方法。这个量表的单位被命名为“Centiloids”。基本上，我们描述了一种分析PiB PET数据的“标准”方法，然后是一种将任何PiB PET分析的“非标准”方法（或任何其他示踪剂）按比例换算到Centiloid量表的方法。
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