通往预组织和线性聚氨基多羧酸盐的有效途径：Cy-TTHA、Cy-DTPA以及单/双反应性、丁基保护的TTHA/Cy-TTHA。
Efficient route to pre-organized and linear polyaminopolycarboxylates: Cy-TTHA, Cy-DTPA and mono/di- reactive, -butyl protected TTHA/Cy-TTHA.
作者信息
Mohamadi Ali, Miller Lawrence W
机构信息
University of Illinois at Chicago, Department of Chemistry, 845 W. Taylor Street, MC 111, Chicago, IL 60607.
出版信息
Tetrahedron Lett. 2017 Apr 12;58(15):1441-1444. doi: 10.1016/j.tetlet.2017.02.056. Epub 2017 Feb 20.
Abstract
Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from commercially available starting materials in ~ 62% and 47% overall yields, respectively. Furthermore, strategies are reported for the efficient preparation of mono- and di-reactive, -butyl-protected TTHA/Cy-TTHA to selectively functionalize central chelators' carboxylic acids.
摘要
通过模块化五步合成法，由市售起始原料分别以约62%和47%的总收率合成了预组装的多氨基多羧酸盐螯合剂Cy-TTHA和Cy-DTPA。此外，还报道了高效制备单反应性和双反应性、丁基保护的TTHA/Cy-TTHA的策略，以选择性地官能化中心螯合剂的羧酸。
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