线粒体 DNA 信号在免疫反应中的作用。

Roles of Mitochondrial DNA Signaling in Immune Responses.

机构信息

Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai, China.

Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China.

出版信息

Adv Exp Med Biol. 2017;1038:39-53. doi: 10.1007/978-981-10-6674-0_4.

DOI:10.1007/978-981-10-6674-0_4

PMID:29178068

Abstract

Mitochondrial DNA (mtDNA) plays an important role in immune responses during the evolution. The present chapter systemically describes its role on immune-related diseases and its interaction on immune responses. It is important to explore the main function and mechanisms of mtDNA in immune responses by which mtDNA regulates the signaling pathways of Toll-like receptor 9, autophagy, and STING. There are potentials to discover therapeutic targets of mtDNA in immune diseases and inflammation. It will be more exciting if the CRISPR-Cas9 method can be applied for mtDNA gene editing to cure diseases and provide a novel insight of mtDNA in immune responses as well as new therapies.

摘要

线粒体 DNA（mtDNA）在进化过程中的免疫反应中起着重要作用。本章系统地描述了它在与免疫相关的疾病中的作用及其对免疫反应的相互作用。通过 mtDNA 调节 Toll 样受体 9、自噬和 STING 的信号通路，探索 mtDNA 在免疫反应中的主要功能和机制非常重要。有可能发现免疫疾病和炎症中 mtDNA 的治疗靶点。如果 CRISPR-Cas9 方法可用于 mtDNA 基因编辑来治疗疾病，以及为免疫反应中的 mtDNA 提供新的见解和新的治疗方法，那将更加令人兴奋。