Zhao Yujie, Pan Zhizhong
Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Nov 25;20(11):1246-1250.
The incidence of colorectal cancer (CRC) in China is gradually increasing as a result of the economic development and dietary change. Since it usually takes a long time for precancerous lesions (e.g. adenoma) to develop into cancer, proper cancer screening is useful to discover and to remove these early lesions, while the patients can achieve long-term survival. Hence, developing a well-organized cancer screening system is necessary for the early detection and intervention of potential CRC. Sun Yat-sen University Cancer Center (SYSUCC) has been developing a community-based cancer screening program, using questionnaires and fecal occult blood test to identify the residents with high risks of CRC. These people will be further subjected to colonoscopy and biopsy for the suspected lesions. Among the 1 030 participants in Guangzhou Yuexiu District who received colonoscopy at SYSUCC from January to November in 2015, polyps, inflammation or tumors were found in 361 (35.0%) patients, in whom 13 were colorectal cancers (1.3%), 327 were polyps (31.7%), 239 were adenoma (23.2%), and 140 were prophase adenoma(13.6%). Besides, no significant difference of CRC detection rate between male and female was found (P>0.05), while the detection rate of polyps and prophase adenoma was higher in male than that in female, which also increased significantly with age (P<0.01). We envision such systematic cancer screening extremely useful to enhance the understanding of cancer screening in the public and eventually to realize the early detection and treatment of cancer.
由于经济发展和饮食变化,中国结直肠癌(CRC)的发病率正在逐渐上升。由于癌前病变(如腺瘤)发展成癌症通常需要很长时间,适当的癌症筛查有助于发现并切除这些早期病变,从而使患者获得长期生存。因此,建立一个组织完善的癌症筛查系统对于早期发现和干预潜在的结直肠癌至关重要。中山大学肿瘤防治中心(SYSUCC)一直在开展一项基于社区的癌症筛查项目,通过问卷调查和粪便潜血试验来识别结直肠癌高危居民。这些人将进一步接受结肠镜检查,并对疑似病变进行活检。在2015年1月至11月期间于SYSUCC接受结肠镜检查的广州市越秀区1030名参与者中,361名(35.0%)患者发现有息肉、炎症或肿瘤,其中13例为结直肠癌(1.3%),327例为息肉(31.7%),239例为腺瘤(23.2%),140例为前期腺瘤(13.6%)。此外,未发现男性和女性之间的结直肠癌检出率有显著差异(P>0.05),而男性的息肉和前期腺瘤检出率高于女性,且随年龄增长也显著增加(P<0.01)。我们设想这样的系统癌症筛查对于提高公众对癌症筛查的认识并最终实现癌症的早期发现和治疗非常有用。