Boussouf Khaira, Zaidi Zoubida, Amrane Mounira, Hammoudi Naima, Mebarki Malika, Amalou Sid Ali
Department of Cardiology, University Hospital of Ben Aknoun, Algiers, Algeria; Genetics Laboratory of Cardiovascular Diseases, Sétif, Algeria.
Department of Epidemiology, University Hospital of Ben Aknoun, Algiers, Algeria; Genetics Laboratory of Cardiovascular Diseases, Sétif, Algeria.
East Mediterr Health J. 2017 Nov 19;23(9):632-636. doi: 10.26719/2017.23.9.632.
This study aimed to describe and evaluate the type, frequency and patterns of congenital heart diseases (CHDs) in patients with Down Syndrome (DS) in Sétif, Algeria. Down Syndrome, or trisomy 21, is the most common genetic disorder in the world. Data were collected and followed from January 2009 to December 2013. Parental consanguinity documenting pedigree analyzing, chromosome analysis and clinical examination were carried out for all cases. Results have shown that 22 (15.4%; ± 0.06) of the total 143 known cases of DS from DS centres have CHDs and 88 (10.6%; ± 2.2) of the total 770 patients with CHDs collected from public departments at the child and maternity teaching hospital, Sétif, have DS. Among the 110 cases, 75 (68%) have single cardiac abnormalities and 35 (32%) have multiple cardiac abnormalities. The most frequent CHDs were Atrioventricular Septal Defect (AVSD). In conclusion, our study will be helpful to demonstrate the current status of DS and to identify the distribution of CHD in patients with DS in Sétif, Algeria, for further study.
本研究旨在描述和评估阿尔及利亚塞提夫地区唐氏综合征（DS）患者先天性心脏病（CHD）的类型、频率和模式。唐氏综合征，即21三体综合征，是世界上最常见的遗传疾病。研究收集了2009年1月至2013年12月的数据并进行随访。对所有病例进行了记录系谱分析的父母近亲关系调查、染色体分析和临床检查。结果显示，来自DS中心的143例已知DS病例中，有22例（15.4%；±0.06）患有CHD；在塞提夫儿童与妇产教学医院公共部门收集的770例CHD患者中，有88例（10.6%；±2.2）患有DS。在这110例病例中，75例（68%）有单一心脏异常，35例（32%）有多种心脏异常。最常见的CHD是房室间隔缺损（AVSD）。总之，我们的研究将有助于展示DS的现状，并确定阿尔及利亚塞提夫地区DS患者中CHD的分布情况，以供进一步研究。
