Patton State Hospital, Patton, CA, United States.
Loma Linda University, Loma Linda, CA, United States.
Mech Ageing Dev. 2018 Sep;174:63-75. doi: 10.1016/j.mad.2017.11.012. Epub 2017 Nov 24.
Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing prevention of neurodegenerative disorders within reach. In this review, we take a closer look at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.
衰老是许多细胞类型中铁质潴留的相关因素，包括神经元，通过铁死亡促进神经退行性变。过多的细胞内铁通过破坏 DNA 和阻止基因组修复系统来加速衰老，我们将这个过程定义为铁衰老。新的神经影像学和蛋白质组学技术已经确定了铁潴留和铁衰老的指标，这使得它们能够早期得到纠正，从而有可能使预防神经退行性疾病成为可能。在这篇综述中，我们仔细研究了神经退行性疾病中铁质失调的早期标志物，重点介绍了基于营养和微生物组操作的预防策略。
