艾米卡星素 A-J，地中海拟无枝酸菌 S699∆rifA 产生的五角形多酚。
Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA.
机构信息
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong, 250012, People's Republic of China.
State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, 250100, People's Republic of China.
出版信息
Appl Microbiol Biotechnol. 2018 Jan;102(2):689-702. doi: 10.1007/s00253-017-8648-z. Epub 2017 Nov 27.
Ten new pentangular polyphenols, namely amexanthomycins A-J (1-10) were isolated from the strain Amycolatopsis mediterranei S699∆rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A-C (1-3) showed inhibitory activity against human DNA topoisomerases.
从构建的 rifamycin 生物合成基因缺失的链霉菌 Amycolatopsis mediterranei S699∆rifA 菌株中分离得到 10 个新的五角形多酚，即 amexanthomycins A-J（1-10）。根据 1D 和 2D NMR 波谱数据和高分辨率 ESIMS，解析了它们的结构。Amexanthomycins A-C（1-3）显示出对人 DNA 拓扑异构酶的抑制活性。
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