PlncRNA-1和TUG1的异常表达：胃癌诊断及临床监测癌症进展的潜在生物标志物
Aberrant expression of PlncRNA-1 and TUG1: potential biomarkers for gastric cancer diagnosis and clinically monitoring cancer progression.
作者信息
Baratieh Zohreh, Khalaj Zahra, Honardoost Mohammad Amin, Emadi-Baygi Modjtaba, Khanahmad Hossein, Salehi Mansoor, Nikpour Parvaneh
机构信息
Department of Genetics & Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Division of Cellular & Molecular Biology, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
出版信息
Biomark Med. 2017 Dec;11(12):1077-1090. doi: 10.2217/bmm-2017-0090. Epub 2017 Nov 28.
AIM
To evaluate PlncRNA-1, TUG1 and FAM83H-AS1 gene expression and their possible role as a biomarker in gastric cancer (GC) progression.
PATIENTS & METHODS: Long noncoding RNA expressions and clinicopathological characteristics were assessed in 70 paired GC tissues. Furthermore, corresponding data from 318 GC patients were downloaded from The Cancer Genome Atlas database.
RESULTS
Expression of PlncRNA-1 and TUG1 were significantly upregulated in GC tumoral tissues, and significantly correlated with clinicopathological characters. However, FAM83H-AS1 showed no consistently differential expression. The expression of these three long noncoding RNAs was significantly higher in The Cancer Genome Atlas tumoral tissues.
CONCLUSION
In conclusion, PlncRNA-1 and TUG1 genes may play a critical role in GC progression and may serve as potential diagnostic biomarkers in GC patients.
目的
评估PlncRNA-1、TUG1和FAM83H-AS1基因表达及其作为生物标志物在胃癌（GC）进展中的可能作用。
患者与方法
对70对GC组织进行长链非编码RNA表达及临床病理特征评估。此外，从癌症基因组图谱数据库下载了318例GC患者的相应数据。
结果
PlncRNA-1和TUG1在GC肿瘤组织中的表达显著上调，且与临床病理特征显著相关。然而，FAM83H-AS1未表现出一致的差异表达。这三种长链非编码RNA在癌症基因组图谱肿瘤组织中的表达显著更高。
结论
总之，PlncRNA-1和TUG1基因可能在GC进展中起关键作用，并可能作为GC患者潜在的诊断生物标志物。
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