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新型长链非编码RNA LINC00941通过激活MYC促进结肠癌的增殖和侵袭。

Novel lncRNA LINC00941 Promotes Proliferation and Invasion of Colon Cancer Through Activation of MYC.

作者信息

Chang Lin, Zhou Dongmin, Luo Suxia

机构信息

Intensive Care Unit, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.

Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.

出版信息

Onco Targets Ther. 2021 Feb 22;14:1173-1186. doi: 10.2147/OTT.S293519. eCollection 2021.

DOI:10.2147/OTT.S293519
PMID:33654409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7910107/
Abstract

PURPOSE

We conducted the study to elucidate how LncRNA LINC00941 affects colon cancer progression and its possible regulatory mechanism.

METHODS

The expression level of LINC00941 in colon cancer tissues and cells was detected by qRT-PCR. The function of LINC00941 on colon cancer cell proliferation, migration, and invasion was detected by CCK-8 and Transwell assay respectively. The target interactions among LINC00941, miR-205-5p, and MYC were further confirmed by dual-luciferase reporter gene assays and RNA pull-down experiments. Meanwhile, in vivo experiments were carried out to study the role of LINC00941 in the xenotransplantation model.

RESULTS

LINC00941 expression level was elevated in colon cancer tissues and cells. LINC00941 overexpression accelerated proliferation, migration, and invasion of colon cancer cells, while the LINC00941 knockdown showed the opposite results. In addition, LINC00941 regulated the expression of MYC by sponging miR-205-5p as a competitive endogenous RNA, and miR-205-5p knockdown reversed the tumor inhibition of LINC00941 knockdown on colon cancer cells. Xenograft model assay confirmed that LINC00941 silencing could inhibit colon cancer cell growth and metastasis.

CONCLUSION

LINC00941 may markedly promote colon cancer progression by acting on the miR-205-5p/MYC axis as a ceRNA, which offers novel clues for lncRNA to guide the treatment and prognosis of colon cancer.

摘要

目的

我们开展本研究以阐明长链非编码RNA LINC00941如何影响结肠癌进展及其可能的调控机制。

方法

采用qRT-PCR检测结肠癌组织和细胞中LINC00941的表达水平。分别通过CCK-8和Transwell实验检测LINC00941对结肠癌细胞增殖、迁移和侵袭的作用。通过双荧光素酶报告基因实验和RNA下拉实验进一步证实LINC00941、miR-205-5p和MYC之间的靶向相互作用。同时，进行体内实验以研究LINC00941在异种移植模型中的作用。

结果

结肠癌组织和细胞中LINC00941表达水平升高。LINC00941过表达促进结肠癌细胞的增殖、迁移和侵袭，而敲低LINC00941则产生相反结果。此外，LINC00941作为竞争性内源性RNA通过海绵吸附miR-205-5p来调控MYC的表达，敲低miR-205-5p可逆转LINC00941敲低对结肠癌细胞的肿瘤抑制作用。异种移植模型实验证实LINC00941沉默可抑制结肠癌细胞生长和转移。

结论

LINC00941可能作为一种竞争性内源RNA通过作用于miR-205-5p/MYC轴显著促进结肠癌进展，这为lncRNA指导结肠癌的治疗和预后提供了新线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec51/7910107/232f765f5919/OTT-14-1173-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec51/7910107/55f6f07a3b02/OTT-14-1173-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec51/7910107/232f765f5919/OTT-14-1173-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec51/7910107/55f6f07a3b02/OTT-14-1173-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec51/7910107/232f765f5919/OTT-14-1173-g0005.jpg

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