Nguyen Van Tuan, Do Le Quyen, Nguyen The Anh, Nguyen Tuan Thanh, Tran Van Loc, Ho Ngoc Anh, Tran Van Chien, Tran Van Sung, Tran Thi Phuong Thao
a Department of Pharmacy , Asean College , Van Lam, Hung Yen , Vietnam.
b Graduate University of Science and Technology, Vietnam Academy of Science and Technology , Hanoi , Vietnam.
J Asian Nat Prod Res. 2018 Sep;20(9):889-896. doi: 10.1080/10286020.2017.1406927. Epub 2017 Nov 28.
Two new cycloartanes, named dolichandrone A (1) and dolichandrone B (2), as well as two new iridoids, named [6-O-[(E)-4-methoxycinnamoyl]-1β-hydroxy-dihydrocatalpolgenin (3) and 6-O-[(E)-4-methoxycinnamoyl]-1α-hydroxy-dihydrocatalpolgenin (4), together with four known iridoids (5-8), were isolated from the leaves and barks of Dolichandrone spathacea. Their structures were elucidated by means of extensive analysis of their HRESIMS, 1D and 2D NMR spectroscopic data. All of these compounds have been isolated for the first time from this plant. Compounds 1, 2, 5, and 7 were evaluated for their cytotoxic activity in vitro against four human cancer cell lines KB, Lu, HepG2, and MCF7. The results showed that only compound 2 exhibited a good cytotoxicity against KB cell line with IC of 18.77 μM.
从长花芒毛苣苔的叶和茎皮中分离出两个新的环阿尔廷烷类化合物，分别命名为长花芒毛苣苔素A（1）和长花芒毛苣苔素B（2），以及两个新的环烯醚萜类化合物，分别命名为[6 - O - [(E)-4 - 甲氧基肉桂酰基]-1β - 羟基 - 二氢梓醇苷元（3）和6 - O - [(E)-4 - 甲氧基肉桂酰基]-1α - 羟基 - 二氢梓醇苷元（4），同时还分离出四个已知的环烯醚萜类化合物（5 - 8）。通过对它们的高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振光谱数据进行广泛分析，阐明了它们的结构。所有这些化合物均首次从该植物中分离得到。对化合物1、2、5和7进行了体外对四种人癌细胞系KB、Lu、HepG2和MCF7的细胞毒活性评价。结果表明，只有化合物2对KB细胞系表现出良好的细胞毒性，其半数抑制浓度（IC）为18.77 μM。
