山茱萸叶中的三种新环烯醚萜类化合物。

Three new iridoids from leaves of Cornus officinalis.

作者信息

Li Yong-Chao, Yang Jing, Wu Xing-Gang, Xu Xin-Juan, Fu Qing-Yun

机构信息

a Life School of Science and Technology, Henan Institute of Science and Technology , Xinxiang 453003 , China.

出版信息

J Asian Nat Prod Res. 2015;17(8):788-92. doi: 10.1080/10286020.2015.1026809. Epub 2015 Apr 28.

DOI:10.1080/10286020.2015.1026809

PMID:25917074

Abstract

Three new iridoids, cornifins A-C (1-3), together with a known iridoid, were obtained from EtOAc layer of leaves of Cornus officinalis. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activity against lung cancer cell line A-549 with IC50 value of 29.1 μM.

摘要

从山茱萸叶的乙酸乙酯层中获得了三种新的环烯醚萜类化合物，山茱萸苷A-C（1-3），以及一种已知的环烯醚萜类化合物。通过广泛的光谱分析阐明了新化合物的结构。化合物2对肺癌细胞系A-549显示出微弱的抑制活性，IC50值为29.1μM。