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α-平滑肌肌动蛋白是平滑肌细胞的一种分化标志物,存在于周细胞的微丝束中。

Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes.

作者信息

Skalli O, Pelte M F, Peclet M C, Gabbiani G, Gugliotta P, Bussolati G, Ravazzola M, Orci L

机构信息

Department of Pathology, University of Geneva, Switzerland.

出版信息

J Histochem Cytochem. 1989 Mar;37(3):315-21. doi: 10.1177/37.3.2918221.

Abstract

alpha-Smooth muscle (alpha-sm) actin, an isoform typical of smooth muscle cells (SMC) and present in high amounts in vascular SMC, was demonstrated in the cytoplasm of pericytes of various rat and human organs by means of immunocytochemistry at the electron microscopic level. In SMC and pericytes, alpha-sm actin was localized in microfilament bundles, strengthening the assumption that it is the functional isoform in these cell types and supporting the assumption that pericytes exert contractile functions.

摘要

α-平滑肌(α-sm)肌动蛋白是平滑肌细胞(SMC)的一种典型亚型,在血管平滑肌细胞中大量存在。通过电子显微镜水平的免疫细胞化学方法,在各种大鼠和人类器官的周细胞胞质中证实了α-sm肌动蛋白的存在。在平滑肌细胞和周细胞中,α-sm肌动蛋白定位于微丝束中,这强化了它是这些细胞类型中的功能性亚型这一假设,并支持周细胞发挥收缩功能的假设。

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