Mikolašević Ivana, Orlić Lidija, Štimac Davor, Mavrinac Vojko, Colić Marina, Ostojić Daniela, Milić Sandra
Lijec Vjesn. 2016 May;138(5-6):159-163.
XNonalcoholic fatty liver disease (NAFLD) has become a common cause of elevated liver tests. The association between fatty liver and metabolic syndrome (MS) is well documented and widely accepted. Cirrhosis due to nonalcoholic steatohepatitis (NASH) is currently the second most common indication for liver transplant with increasing incidence. Gastroenterologists/hepathologists and primary care physicians have more questions than answers regarding the NAFLD. The most common questions are which NAFLD patients have a risk of progression to NASH, fibrosis, cirrhosis and hepa- tocellular carcinoma, and which patients with NAFLD have a need for liver biopsy. In addition, a number of non-invasive diagnostic methods in the approach to the patient with NAFLD are investigated. How to approach these patients in routine clinical practice, is more of an art than a science at this time. In this article we will try to provide more recent recommenda- tions of how to approach the patients with NAFLD.
非酒精性脂肪性肝病（NAFLD）已成为肝功能检查异常的常见原因。脂肪肝与代谢综合征（MS）之间的关联已有充分记录且被广泛认可。目前，非酒精性脂肪性肝炎（NASH）所致肝硬化是肝移植的第二大常见适应证，且发病率不断上升。胃肠病学家/肝病学家和初级保健医生对NAFLD的疑问多于答案。最常见的问题是哪些NAFLD患者有进展为NASH、纤维化、肝硬化和肝细胞癌的风险，以及哪些NAFLD患者需要进行肝活检。此外，针对NAFLD患者的多种非侵入性诊断方法也在研究中。目前，在常规临床实践中如何处理这些患者更多的是一门艺术而非科学。在本文中，我们将尝试提供关于如何处理NAFLD患者的最新建议。
