Lenz Destin U, Crutcher Effie L, Greene Elisa M
1 Belmont University College of Pharmacy, Nashville, TN, USA.
2 Siloam Family Health Center, Nashville, TN, USA.
J Pharm Pract. 2019 Apr;32(2):231-235. doi: 10.1177/0897190017744421. Epub 2017 Nov 28.
Sexual dysfunction is a bothersome side effect of several medications, though it has not yet been reported with the use of ledipasvir/sofosbuvir for the treatment of hepatitis C. However, sexual dysfunction is a potentially unrecognized side effect of ledipasvir/sofosbuvir that could result in nonadherence and treatment failure. We report a case of a 42-year-old man with a sudden onset of sexual dysfunction with the initiation of ledipasvir/sofosbuvir for the treatment of hepatitis C. The patient had no prior history or risk factors for the development of sexual dysfunction. His symptoms resolved upon discontinuation of ledipasvir/sofosbuvir after a successful 12-week course. Clinicians should be aware that sexual dysfunction is a possible side effect of ledipasvir/sofosbuvir and educate patients appropriately. Adherence should be emphasized as the risks of untreated hepatitis C virus far outweigh transient sexual dysfunction.
性功能障碍是多种药物令人困扰的副作用，不过，使用来迪派韦/索磷布韦治疗丙型肝炎尚未有相关报道。然而，性功能障碍可能是来迪派韦/索磷布韦未被识别的副作用，可能导致治疗依从性差及治疗失败。我们报告一例42岁男性患者，在开始使用来迪派韦/索磷布韦治疗丙型肝炎后突然出现性功能障碍。该患者既往无性功能障碍病史或风险因素。在成功完成12周疗程后停用该药物，其症状得以缓解。临床医生应意识到性功能障碍可能是来迪派韦/索磷布韦的副作用，并对患者进行适当教育。应强调治疗依从性，因为未经治疗的丙型肝炎病毒的风险远超过短暂的性功能障碍。
