弯曲杆菌与幽门螺杆菌菌血症的临床和微生物学特征比较：使用BACTEC血培养系统时血培养阳性时间的重要性。
Comparison of the clinical and microbiological characteristics of Campylobacter and Helicobacter bacteremia: the importance of time to blood culture positivity using the BACTEC blood culture systems.
作者信息
Yamamoto Kei, Hayakawa Kayoko, Nagashima Maki, Shimada Kayo, Kutsuna Satoshi, Takeshita Nozomi, Kato Yasuyuki, Kanagawa Shuzo, Yamada Koji, Mezaki Kazuhisa, Kirikae Teruo, Ohmagari Norio
机构信息
Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
出版信息
BMC Res Notes. 2017 Nov 28;10(1):634. doi: 10.1186/s13104-017-2981-2.
OBJECTIVE
Campylobacter spp. and Helicobacter spp. are rare but important causes of bacteremia in humans. Distinguishing these bacteria is complicated because of their similar phenotypic profiles. We conducted clinical and microbiological investigations of Campylobacter spp. or Helicobacter spp. bacteremia. Patients diagnosed with bacteremia from 2008 to 2014 were included. The clinical and microbiological characteristics of Campylobacter spp. and Helicobacter spp. bacteremia were compared. The BACTEC system was used in blood cultures. A receiver operating characteristic curve was plotted based on the time to blood culture positivity.
RESULTS
Sixteen cases of Helicobacter spp. bacteremia (patient age: 61 ± 18 years) and 14 cases of Campylobacter spp. bacteremia (patient age: 49 ± 21 years) were identified. Median time to blood culture positivity was longer for the Helicobacter spp. cases than the Campylobacter spp. cases (91.4 h vs 55.3 h, p < 0.01). A time to blood culture positivity > 75 h predicted Helicobacter spp. bacteremia with a sensitivity of 0.88 and a specificity of 0.93 (area under the receiver operating characteristic curve of 0.90). In conclusion, a time to blood culture positivity was useful in distinguishing Helicobacter spp. bacteremia from Campylobacter spp. bacteremia.
目的
弯曲杆菌属和螺杆菌属是人类菌血症罕见但重要的病因。由于它们的表型特征相似，区分这些细菌很复杂。我们对弯曲杆菌属或螺杆菌属菌血症进行了临床和微生物学调查。纳入了2008年至2014年被诊断为菌血症的患者。比较了弯曲杆菌属和螺杆菌属菌血症的临床和微生物学特征。血培养采用BACTEC系统。根据血培养阳性时间绘制受试者工作特征曲线。
结果
确定了16例螺杆菌属菌血症病例（患者年龄：61±18岁）和14例弯曲杆菌属菌血症病例（患者年龄：49±21岁）。螺杆菌属病例血培养阳性的中位时间比弯曲杆菌属病例长（91.4小时对55.3小时，p<0.01）。血培养阳性时间>75小时预测螺杆菌属菌血症的敏感性为0.88，特异性为0.93（受试者工作特征曲线下面积为0.90）。总之，血培养阳性时间有助于区分螺杆菌属菌血症和弯曲杆菌属菌血症。
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