Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing 100193, P.R. China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing 100193, P.R. China.
Pestic Biochem Physiol. 2017 Nov;143:161-167. doi: 10.1016/j.pestbp.2017.08.002. Epub 2017 Aug 5.
In this study, H NMR based metabolomics analysis, LC-MS/MS based serum metabolomics and histopathology techniques were used to investigate the toxic effects of subacute exposure to two types of pyrethroid insecticides bifenthrin and lambda-cyhalothrin in mice. Metabolomic analysis of tissues extracts and serum showed that these two types of pyrethroid insecticides resulted in alterations of metabolites in the liver, kidney and serum of mice. Based on the altered metabolites, several significant pathways were identified, which are associated with gut microbial metabolism, lipid metabolism, nucleotide catabolism, tyrosine metabolism and energy metabolism. The results showed that bifenthrin and lambda-cyhalothrin have similarities in disruption of metabolic pathways in kidney, indicating that the toxicological mechanisms of these two types of insecticides have some likeness to each other. This study may provide novel insight into revealing differences of toxicological mechanisms between these two types of pyrethroid insecticides.
在这项研究中，采用基于 1H NMR 的代谢组学分析、基于 LC-MS/MS 的血清代谢组学和组织病理学技术，研究了两种拟除虫菊酯杀虫剂（功夫菊酯和高效氯氟氰菊酯）亚急性暴露对小鼠的毒性作用。组织提取物和血清的代谢组学分析表明，这两种拟除虫菊酯杀虫剂导致小鼠肝脏、肾脏和血清中的代谢物发生变化。基于改变的代谢物，确定了几个重要的途径，这些途径与肠道微生物代谢、脂质代谢、核苷酸分解代谢、酪氨酸代谢和能量代谢有关。结果表明，功夫菊酯和高效氯氟氰菊酯在肾脏代谢途径的破坏方面具有相似性，表明这两种杀虫剂的毒理学机制有一些相似之处。本研究可能为揭示这两种拟除虫菊酯杀虫剂的毒理学机制差异提供新的见解。
