Al-Sarar Ali S, Abobakr Yasser, Bayoumi Alaa E, Hussein Hamdy I, Al-Ghothemi Mousa
Plant Protection Department, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Environ Toxicol. 2014 May;29(7):750-62. doi: 10.1002/tox.21802. Epub 2012 Aug 6.
Lambda-cyhalothrin (LCT) is a widely used broad-spectrum pyrethroid insecticide. Oral LCT administration to adult male mice at 3 doses (0.2, 0.4, and 0.8 mg/kg/day) for 6 weeks caused a significant reduction in the weight of the seminal vesicles. The epididymal sperm count was lower in mice that received at the highest dose than in control mice. However, the proportions of live and motile spermatozoa were reduced at both the medium and the high doses compared with control mice. All doses induced an increase in the number of morphologically abnormal spermatozoa. Histopathological observations of the testes, liver, kidneys, and spleen showed dose-related degenerative damage in LCT-treated mice. The results indicate that LCT has reproductive toxicity, hepatotoxicity, nephrotoxicity, and splenotoxicity in male mice at the tested doses. © 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 750-762, 2014.
高效氯氟氰菊酯（LCT）是一种广泛使用的广谱拟除虫菊酯类杀虫剂。以3种剂量（0.2、0.4和0.8毫克/千克/天）对成年雄性小鼠进行为期6周的口服LCT给药，导致精囊重量显著减轻。接受最高剂量的小鼠附睾精子计数低于对照小鼠。然而，与对照小鼠相比，中剂量和高剂量组的活精子和活动精子比例均降低。所有剂量均导致形态异常精子数量增加。对睾丸、肝脏肾脏和脾脏的组织病理学观察显示，LCT处理的小鼠存在剂量相关的退行性损伤。结果表明，在所测试的剂量下，LCT对雄性小鼠具有生殖毒性、肝毒性、肾毒性和脾毒性。©2012威利期刊公司。《环境毒理学》29:750 - 762，2014年。
