Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center for Diabetes, Shanghai, China.
Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Sci Rep. 2017 Nov 28;7(1):16482. doi: 10.1038/s41598-017-16312-6.
Fibroblast growth factor 21 (FGF21), a stress-induced hormone in the liver, has been shown the protective functions in pathological conditions. The study investigated the association of circulating FGF21 with hepatitis B virus (HBV) infection and its related diseases. Serum FGF21 levels were measured in 33 acute hepatitis B (AHB), 75 chronic hepatitis B (CHB) and 66 CHB patients with advanced liver diseases including liver cirrhosis, acute-on-chronic liver failure (ALCF) and hepatocellular carcinoma (HCC) together with 200 age- and BMI-matched healthy controls. FGF21 levels were significantly increased in AHB patients and rapidly returned to normal levels after treatment. FGF21 levels reflected the degree of liver injury caused by AHB. However, serum FGF21 levels were decreased in CHB patients especially in those who developed cirrhosis and were associated with hepatic protein synthesis capacity. Serum FGF21 in CHB patients were increased with the occurrence of ACLF. Notably, in CHB patients who developed HCC, serum FGF21 exhibited a dramatic increase, which may provide important information on monitoring tumorigenesis in CHB patients. In conclusion, we revealed the diverse changes of circulating FGF21 in HBV-related diseases. FGF21 may be a useful biomarker in monitoring the tumorigenesis in patients with CHB.
成纤维细胞生长因子 21（FGF21）是肝脏中一种应激诱导的激素，已被证明具有在病理条件下的保护功能。本研究调查了循环 FGF21 与乙型肝炎病毒（HBV）感染及其相关疾病的关联。在 33 例急性乙型肝炎（AHB）、75 例慢性乙型肝炎（CHB）和 66 例伴有肝硬化、慢加急性肝衰竭（ALCF）和肝细胞癌（HCC）等进展性肝病的 CHB 患者以及 200 名年龄和 BMI 匹配的健康对照者中测量了血清 FGF21 水平。AHB 患者的 FGF21 水平显著升高，并在治疗后迅速恢复正常水平。FGF21 水平反映了 AHB 引起的肝损伤程度。然而，CHB 患者的血清 FGF21 水平降低，尤其是那些发展为肝硬化的患者，且与肝脏蛋白质合成能力相关。CHB 患者发生 ACLF 时血清 FGF21 增加。值得注意的是，在发生 HCC 的 CHB 患者中，血清 FGF21 显著升高，这可能为监测 CHB 患者的肿瘤发生提供重要信息。总之，我们揭示了 HBV 相关疾病中循环 FGF21 的多样化变化。FGF21 可能是监测 CHB 患者肿瘤发生的有用生物标志物。
