Smith Sarah M, Baker Michael, Halebian Mary, Smith Corinne J
School of Life Sciences, University of Warwick, Coventry, United Kingdom.
Front Mol Biosci. 2017 Nov 14;4:72. doi: 10.3389/fmolb.2017.00072. eCollection 2017.
Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interactions implicated in clathrin-mediated endocytosis, with a particular focus on the two key proteins: AP2 and clathrin.
网格蛋白介导的内吞作用是一个特定分子从细胞周边被内化并输送到早期内体的过程。在这个逐步进行的过程中，从货物识别的起始点到网格蛋白包被组装的后期阶段，关键步骤依赖于大量蛋白质网络之间的弱相互作用。本综述讨论了相关的结构和功能数据，这些数据增进了我们对网格蛋白介导的内吞作用中主要弱分子相互作用的认识和理解，特别关注两种关键蛋白：AP2和网格蛋白。
