Department of Chemistry, University of Florida , 214 Leigh Hall, Gainesville, Florida 32611, United States.
Org Lett. 2017 Dec 15;19(24):6558-6561. doi: 10.1021/acs.orglett.7b03275. Epub 2017 Nov 29.
A robust, convergent, and efficient strategy was developed for the synthesis of the nonasaccharide cancer antigen KH-1. This strategy featured a one-pot block assembly of the linear hexasaccharide backbone using three disaccharides followed by grafting of three fucose residues onto the backbone in one step.
本文发展了一种强韧、汇聚、高效的策略,用于合成非九糖癌症抗原 KH-1。该策略的特点是通过一锅法,使用三个二糖构建线性六糖主链,然后在一步中向主链上接枝三个岩藻糖残基。