错配修复偏好外显子。
Mismatch repair prefers exons.
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
出版信息
Nat Genet. 2017 Nov 29;49(12):1673-1674. doi: 10.1038/ng.3993.
DOI:10.1038/ng.3993
PMID:29186127
Abstract
A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.
摘要
一项对癌症基因组的新分析表明，与预期相比，外显子的突变负担减少，但内含子没有减少。这种差异可以通过 DNA 错配修复机制优先招募到标记外显子的蛋白质修饰来解释。
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