Obata Yurie, Ruzankin Pavel, Berkowitz Dan E, Steppan Jochen, Barodka Viachaslau
Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Sobolev Institute of Mathematics, Novosibirsk, Russia.
PLoS One. 2017 Nov 29;12(11):e0187781. doi: 10.1371/journal.pone.0187781. eCollection 2017.
Pulse wave velocity (PWV) has been recommended as an arterial damage assessment tool and a surrogate of arterial stiffness. However, the current technology does not allow to measure PWV both continuously and in real-time. We reported previously that peripherally measured ejection time (ET) overestimates ET measured centrally. This difference in ET is associated with the inherent vascular properties of the vessel. In the current study we examined ETs derived from plethysmography simultaneously at different peripheral locations and examined the influence of the underlying arterial properties on ET prolongation by changing the subject's position. We calculated the ET difference between two peripheral locations (ΔET) and its corresponding PWV for the same heartbeat. The ΔET increased with a corresponding decrease in PWV. The difference between ΔET in the supine and standing (which we call ET index) was higher in young subjects with low mean arterial pressure and low PWV. These results suggest that the difference in ET between two peripheral locations in the supine vs standing positions represents the underlying vascular properties. We propose ΔET in the supine position as a potential novel real-time continuous and non-invasive parameter of vascular properties, and the ET index as a potential non-invasive parameter of vascular reactivity.
脉搏波速度（PWV）已被推荐作为一种动脉损伤评估工具和动脉僵硬度的替代指标。然而，目前的技术无法实现连续实时测量PWV。我们之前报道过，外周测量的射血时间（ET）高于中心测量的ET。ET的这种差异与血管的固有特性有关。在本研究中，我们在不同外周位置同时检测了通过体积描记法得出的ET，并通过改变受试者体位研究了潜在动脉特性对ET延长的影响。我们计算了同一心跳下两个外周位置之间的ET差值（ΔET）及其相应的PWV。ΔET随着PWV相应降低而增加。在平均动脉压和PWV较低的年轻受试者中，仰卧位和站立位的ΔET差值（我们称之为ET指数）更高。这些结果表明，仰卧位和站立位两个外周位置之间的ET差异代表了潜在的血管特性。我们提出，仰卧位的ΔET作为血管特性潜在的新型实时连续无创参数，而ET指数作为血管反应性的潜在无创参数。
