Deemer J P, Tsaknis P J
Oral Surg Oral Med Oral Pathol. 1979 Oct;48(4):358-73. doi: 10.1016/0030-4220(79)90037-9.
Polyethylene tubes obturated flush at one end overfilled 2 mm. at the opposite end with unset Grossman's cement and gutta-percha were implanted in rat tibias. Microscopic evaluation of the specimens revealed that (1) the gutta-percha, Grossman's sealer, and polyethylene tubing are well tolerated by rat intraosseous tissue and (2) a canal overextended 2 mm. beyond the apex with Grossman's cement and gutta-percha produces an early mild to moderate inflammatory response which resolves by the end of 30 day's. The overfillings did not significantly compromise the healing of rat intraosseous tissue.
将一端齐平封闭、另一端用未凝固的格罗斯曼粘固剂和牙胶超填2毫米的聚乙烯管植入大鼠胫骨。对标本的显微镜评估显示：（1）大鼠骨内组织对牙胶、格罗斯曼封闭剂和聚乙烯管耐受性良好；（2）用格罗斯曼粘固剂和牙胶超出根尖2毫米进行根管超填会产生早期轻度至中度炎症反应，该反应在30天结束时消退。超填并未显著影响大鼠骨内组织的愈合。
