Tanzilli J P, Nevins A J, Borden B G
Oral Surg Oral Med Oral Pathol. 1983 May;55(5):507-13. doi: 10.1016/0030-4220(83)90237-2.
A subcutaneous tube implant study was conducted on adult Sprague-Dawley rats. Polyethylene tubes sealed at one end were filled flush to the open end with Hydron or gutta-percha and sealer. These implants were immediately placed into dorsal subcutaneous connective tissue for periods ranging from three weeks to 6 months. Tubes filled with Hydron demonstrated expansion and resorption of material with its distribution into connective tissue. A moderately thick connective tissue capsule containing macrophages formed at the tissue-Hydron interface. Amorphous calcific deposits were localized within Hydron, being most dense at the Hydron--tissue interface. Tubes filled with gutta-percha and sealer demonstrated thinner connective tissue capsule formation, with little or no distribution or resorption of material. A mild lymphocyte response was noted within the capsule adjacent to the gutta-percha.
对成年斯普拉格-道利大鼠进行了皮下管植入研究。一端密封的聚乙烯管被填充到开口端平齐的Hydron或牙胶及封闭剂。这些植入物立即被置于背部皮下结缔组织中，放置时间从三周至6个月不等。填充Hydron的管子显示材料有膨胀和吸收，并分布到结缔组织中。在组织-Hydron界面形成了一个含有巨噬细胞的中等厚度的结缔组织囊。无定形钙化沉积物位于Hydron内，在Hydron-组织界面处最为密集。填充牙胶及封闭剂的管子显示形成的结缔组织囊较薄，材料几乎没有或没有分布或吸收。在靠近牙胶的囊内观察到轻度淋巴细胞反应。
