António Ana Marta, Alves João Vitor, Coelho Ricardo, Bártolo Elvira
Dermatovenereology Service, Hospital Garcia de Orta - Almada, Portugal.
Dermatology Service, Centro Hospitalar Conde de São Januário - Macau, China.
An Bras Dermatol. 2017 May-Jun;92(3):410-412. doi: 10.1590/abd1806-4841.20175355.
Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy. We report a case of a 67-year-old woman with an inflammatory ulcerated plaque in the left masseter region. A skin biopsy showed dense perivascular infiltrate of mature plasma cells in the dermis without atypia and immunoglobulin light chain restriction. After physical examination and further investigation, we ruled out systemic disease. Our patient was successfully treated only with hydrocortisone cream application. Few cases of isolated benign primary cutaneous plasmacytosis have been described, particularly in children. After excluding the diagnosis of a reactive process to an infection, which is unlikely in this case, we suspected of a rare manifestation of primary cutaneous plasmacytosis in adults with distinct presentation and clinical course.
皮肤和系统性浆细胞增多症是一种罕见的疾病，其特征为皮肤多克隆浆细胞浸润，常伴有多克隆高球蛋白血症和淋巴结病。我们报告一例67岁女性，其左侧咬肌区域有炎性溃疡斑块。皮肤活检显示真皮层有成熟浆细胞密集的血管周围浸润，无异型性且无免疫球蛋白轻链限制。经过体格检查和进一步检查，我们排除了系统性疾病。我们的患者仅通过外用氢化可的松乳膏就成功治愈。很少有孤立性良性原发性皮肤浆细胞增多症的病例被描述，尤其是在儿童中。在排除感染反应性过程的诊断后（在本例中不太可能），我们怀疑这是成人原发性皮肤浆细胞增多症的一种罕见表现，具有独特的表现和临床过程。
