microRNAs 在调控 PD-1/PD-L1 免疫检查点表达中的作用
The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint.
机构信息
Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.
Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.
出版信息
Int J Mol Sci. 2017 Nov 27;18(12):2540. doi: 10.3390/ijms18122540.
Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various cellular processes in cancer. In this review, we focused on the latest progress about microRNAs research which involves the regulation of PD-1/PD-L1 immune checkpoint.
程序性死亡配体 1（PD-L1）与其受体程序性死亡 1（PD-1）在 T 细胞上的结合被推测在抑制免疫系统中发挥主要作用，这有助于肿瘤细胞逃避抗肿瘤免疫。随着全基因组测序技术的发展，microRNAs 作为分子调控的一个重要新层面受到了更多的关注。最近的研究表明，microRNAs 表达的改变在免疫检查点和癌症中的各种细胞过程中起着关键作用。在这篇综述中，我们专注于 microRNAs 研究的最新进展，其中涉及 PD-1/PD-L1 免疫检查点的调节。
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