食管胃交界部癌——通过免疫组织化学鉴别组织学类型
Esophagogastric Junction Carcinomas - Discriminating Histological Types Through Immunohistochemistry.
作者信息
Mochizuki Kunio, Kondo Tetsuo, Oishi Naoki, Tahara Ippei, Inoue Tomohiro, Kasai Kazunari, Nakazawa Tadao, Katoh Ryohei
机构信息
Department of Pathology, School of Medicine, University of Yamanashi, Chuo, Japan
Department of Pathology, School of Medicine, University of Yamanashi, Chuo, Japan.
出版信息
Anticancer Res. 2017 Dec;37(12):6855-6861. doi: 10.21873/anticanres.12147.
BACKGROUND/AIM: Although differentiating squamous cell carcinoma (SCC) from adenocarcinoma (AC) at the esophagogastric junction (EGJ) is important for the choice of treatment, this can occasionally be difficult with small biopsy specimens. Therefore, the purpose of this study was to determine the most useful immunomarker panel for discriminating between SCC and AC of the EGJ.
MATERIALS AND METHODS
We analyzed 15 SCCs and 26 ACs of the EGJ obtained surgically using immunohistochemistry.
RESULTS
The sensitivities of p40, p63 and cytokeratin 5/6 were 100% with specificities of 88%, 46% and 81%, respectively, for SCC. The sensitivities of CAM5.2, caudal-type homeobox 2 (CDX2), mucin-5AC (MUC-5AC) and MUC-6 were 100%, 81%, 77% and 85% with specificities of 27%, 100%, 87% and 87% for AC.
CONCLUSION
We demonstrated that a two-marker panel of p40 and CDX2 is highly sensitive and specific.
背景/目的：虽然区分食管胃交界部（EGJ）的鳞状细胞癌（SCC）和腺癌（AC）对于治疗方案的选择很重要，但对于小活检标本来说，这有时可能会很困难。因此，本研究的目的是确定用于鉴别EGJ的SCC和AC最有用的免疫标志物组合。
材料与方法
我们使用免疫组织化学分析了15例手术获取的EGJ的SCC和26例AC。
结果
p40、p63和细胞角蛋白5/6对SCC的敏感性分别为100%，特异性分别为88%、46%和81%。CAM5.2、尾型同源盒2（CDX2）、黏蛋白5AC（MUC-5AC）和MUC-6对AC的敏感性分别为100%、81%、77%和85%，特异性分别为27%、100%、87%和87%。
结论
我们证明p40和CDX2的双标志物组合具有高度敏感性和特异性。
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