Ploenes T, Aigner C
Abteilung für Thoraxchirurgie und thorakale Endoskopie, Universitätsmedizin Essen - Ruhrlandklinik, Tüschener Weg 40, 45239, Essen, Deutschland.
Chirurg. 2018 Jun;89(6):440-447. doi: 10.1007/s00104-017-0558-1.
Neuroendocrine tumors of the lungs are a very inhomogeneous group of malignancies. The surgical treatment should be adapted to the anatomical localization and histological subtype and individualized according to the functional reserve.
We performed a selective review of current literature, which was supplemented by personal experiences.
The currently available outcome data are very inhomogeneous and depend on the histological subtype of neuroendocrine pulmonary tumors. A radical R0 resection is the key for an improvement in long-term overall and disease-free survival.
Surgical treatment of carcinoid tumors is the current standard therapy. Sleeve resection should be performed, whenever possible. More aggressive tumors, such as large cell neuroendocrine carcinoma and small cell lung cancer should be treated in a multimodal concept.
肺神经内分泌肿瘤是一组非常异质性的恶性肿瘤。手术治疗应根据解剖定位和组织学亚型进行调整，并根据功能储备进行个体化治疗。
我们对当前文献进行了选择性回顾，并结合个人经验进行补充。
目前可用的结果数据非常异质性，且取决于肺神经内分泌肿瘤的组织学亚型。根治性R0切除是改善长期总体生存率和无病生存率的关键。
类癌肿瘤的手术治疗是当前的标准治疗方法。只要有可能，就应进行袖状切除。对于侵袭性更强的肿瘤，如大细胞神经内分泌癌和小细胞肺癌，应采用多模式治疗理念。
