Kyritsis Ioannis, Krebs Bettina, Kampe Sandra, Theegarten Dirk, Aigner Clemens, Welter Stefan
Department of Thoracic Surgery and Endoscopy, Ruhrlandklinik, West German Lung Centre, University of Duisburg-Essen, Essen, Germany.
Department of Anesthesiology, Ruhrlandklinik, West German Lung Centre, University of Duisburg-Essen, Essen, Germany and Department of Anesthesiology and Intensive Care Medicine, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, Germany.
J Thorac Dis. 2017 Feb;9(2):E99-E102. doi: 10.21037/jtd.2017.02.35.
Although neuroendocrine tumors (NETs) of the lung are frequently discussed together, carcinoids are very different from high-grade small cell lung carcinoma (SCLC). SCLC is found in heavy-smoking, older patients, whereas smoking is not strongly associated with carcinoid tumors. We present the case of a 46-year-old never smoking woman who was misdiagnosed with SCLC. The patient was not responsive to radio-chemotherapy plus prophylactic cranial irradiation (PCI); she had a typical carcinoid (TC) tumor according to the final pathology report. We aim to demonstrate that diagnosis of SCLC based on cytology or small biopsy specimens must be scrutinized when the clinical constellation is unusual, or when the follow-up assessment shows no response to systemic treatment.
尽管肺神经内分泌肿瘤（NETs）常被一并讨论，但类癌与高级别小细胞肺癌（SCLC）有很大不同。SCLC多见于重度吸烟的老年患者，而吸烟与类癌肿瘤并无密切关联。我们报告一例46岁从不吸烟的女性患者，她曾被误诊为SCLC。该患者对放化疗加预防性脑照射（PCI）无反应；根据最终病理报告，她患的是典型类癌（TC）肿瘤。我们旨在表明，当临床情况不寻常或后续评估显示对全身治疗无反应时，基于细胞学或小活检标本诊断SCLC必须谨慎审查。
