Abbott Sarah E, Camacho Fabian, Peres Lauren C, Alberg Anthony J, Bandera Elisa V, Bondy Melissa, Cote Michele L, Funkhouser Ellen, Moorman Patricia G, Peters Edward S, Qin Bo, Schwartz Ann G, Barnholtz-Sloan Jill, Terry Paul, Schildkraut Joellen M
Department of Public Health Sciences, University of Virginia, PO Box 800765, Charlottesville, VA, 22903, USA.
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Cancer Causes Control. 2018 Jan;29(1):77-86. doi: 10.1007/s10552-017-0986-8. Epub 2017 Nov 29.
While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populations, although inactivity is more prevalent and survival is poorer among African-American (AA) women. We examined RPA before and after EOC diagnosis and associations with survival among AA women.
We analyzed data from 264 EOC survivors enrolled in a population-based, case-control study who completed surveys that included questions about pre- and post-diagnosis RPA. Data were collected on RPA frequency, intensity, and duration before diagnosis and approximately 1 year after the baseline interview. We calculated metabolic equivalent of task (MET)-hours/week for pre- and post-diagnosis RPA, and evaluated associations with risk of mortality using Cox proportional hazards models.
RPA before diagnosis was not associated with mortality. Hazard ratios (HRs) for post-diagnosis RPA were < 1.0 but not statistically significant after adjustment for covariates; HRs were 0.94 (95% CI 0.58, 1.54) for > 0-9 MET-hours/week and 0.53 (95% CI 0.21, 1.35) for > 9 MET-hours/week.
Our results suggest that RPA may be inversely associated with mortality among AA women with ovarian cancer, although it is possible that the present study was underpowered to detect an association. There is a clear need for more studies of RPA after diagnosis in EOC survivors with attention to potential differences by race.
虽然休闲体育活动（RPA）与乳腺癌、结直肠癌和前列腺癌死亡率降低相关，但上皮性卵巢癌（EOC）方面的证据有限。大多数EOC研究主要针对白人人群，尽管非裔美国（AA）女性中缺乏体育活动更为普遍且生存率更低。我们研究了EOC诊断前后的RPA情况及其与AA女性生存率的关联。
我们分析了一项基于人群的病例对照研究中264名EOC幸存者的数据，这些幸存者完成了包含诊断前后RPA问题的调查问卷。收集了诊断前以及基线访谈后约1年的RPA频率、强度和持续时间数据。我们计算了诊断前后RPA的代谢当量任务（MET）-小时/周，并使用Cox比例风险模型评估与死亡风险的关联。
诊断前的RPA与死亡率无关。诊断后RPA的风险比（HRs）<1.0，但在调整协变量后无统计学意义；每周>0 - 9 MET-小时的HR为0.94（95%CI 0.58，1.54），每周>9 MET-小时的HR为0.53（95%CI 0.21，1.35）。
我们的结果表明，RPA可能与AA卵巢癌女性的死亡率呈负相关，尽管本研究可能因检验效能不足而未检测到关联。显然需要对EOC幸存者诊断后的RPA进行更多研究，并关注种族间的潜在差异。
