Jinmei Zhang, Lei Zhao, Yafei Wu
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Oct 1;35(5):538-542. doi: 10.7518/hxkq.2017.05.018.
In recent years, the study found that Porphyromonas gingivalis type Ⅸ secretion system (T9SS) is a novel protein secretion system, also known as Por secretion system (PorSS). Unlike the eight protein secretion systems found in the past, the system is a polyprotein complex found only in Bacteroides. The secreted proteins have both N- and C-terminus, where the former includes Sec-dependent type Ⅰ signals peptide, and the latter contains conserved domains (C-terminal conserved domain, CTD). Porphyromonas gingivalis T9SS includes proteins such as intima, outer membrane, cytoplasm, and cell cycle, including at least 34 proteins containing CTD. Porphyromonas gingivalis T9SS is involved in regulating associated virulence factors including gingivin, fimbriae, lipopolysaccharide, HBP35, CPG70 protein and peptidyl-arginine deiminase. These CTD-containing virulence proteins are localized by T9SS and then released to the extracellular domain, thereby destroying periodontal tissue. Therefore, this review summarizes the research progress on the T9SS of Porphyromonas gingivalis.
近年来，研究发现牙龈卟啉单胞菌Ⅸ型分泌系统（T9SS）是一种新型蛋白质分泌系统，也称为Por分泌系统（PorSS）。与过去发现的八种蛋白质分泌系统不同，该系统是仅在拟杆菌中发现的多蛋白复合物。分泌蛋白具有N端和C端，前者包括依赖Sec的Ⅰ型信号肽，后者包含保守结构域（C端保守结构域，CTD）。牙龈卟啉单胞菌T9SS包括内膜、外膜、细胞质和细胞周期等蛋白，其中至少有34种含有CTD的蛋白。牙龈卟啉单胞菌T9SS参与调节包括牙龈素、菌毛、脂多糖、HBP35、CPG70蛋白和肽基精氨酸脱亚氨酶在内的相关毒力因子。这些含CTD的毒力蛋白由T9SS定位，然后释放到细胞外区域，从而破坏牙周组织。因此，本综述总结了牙龈卟啉单胞菌T9SS的研究进展。
