巴西国家轮状病毒疫苗计划实施前后流行的轮状病毒基因型：综述。
Rotavirus Genotypes Circulating in Brazil Before and After the National Rotavirus Vaccine Program: A Review.
出版信息
Pediatr Infect Dis J. 2018 Mar;37(3):e63-e65. doi: 10.1097/INF.0000000000001770.
BACKGROUND
Rotavirus vaccines created the opportunity to control diarrhea in children. We describe the rotavirus genotypes before and after the rotavirus vaccine introduction in Brazil.
METHODS
We reviewed the distribution of rotavirus genotypes in Brazil before and after vaccine introduction by searching publication.
RESULTS
Eighty-six studies reported 6884 (15.2%) rotavirus episodes among 45,305 children. Rotavirus caused 22.4% and 11.6% of cases before and after vaccine introduction. G1P[8], G9P[8] and G2P[4] heterotypic strains were most common before and after vaccine introduction.
CONCLUSIONS
The vaccines may have selected heterotypic strains in this highly vaccinated population.
背景
轮状病毒疫苗为控制儿童腹泻提供了契机。本研究描述了巴西引入轮状病毒疫苗前后轮状病毒的基因型。
方法
通过检索文献，我们回顾了巴西引入轮状病毒疫苗前后轮状病毒基因型的分布情况。
结果
86 项研究报告了 45305 名儿童中有 6884 例（15.2%）轮状病毒感染。疫苗引入前后，轮状病毒分别导致 22.4%和 11.6%的病例。疫苗引入前后，G1P[8]、G9P[8]和 G2P[4]异源型株是最常见的。
结论
在这个高接种人群中，疫苗可能选择了异源型株。
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