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急性髓细胞白血病:新靶点与治疗策略。

Acute Myeloid Leukaemia: New Targets and Therapies.

机构信息

Institute of Clinical Science, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

出版信息

Int J Mol Sci. 2017 Nov 30;18(12):2577. doi: 10.3390/ijms18122577.

DOI:10.3390/ijms18122577
PMID:29189736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5751180/
Abstract

The most common acute hematological malignancy in adults is acute myeloid leukaemia (AML), accounting for more than 80% of cases in patients over 60 years of age [...].

摘要

成人中最常见的急性血液病恶性肿瘤是急性髓系白血病(AML),占 60 岁以上患者病例的 80%以上[...]。

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Int J Mol Sci. 2017 Oct 31;18(11):2289. doi: 10.3390/ijms18112289.
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Clinical Outcomes and Co-Occurring Mutations in Patients with RUNX1-Mutated Acute Myeloid Leukemia.RUNX1 突变型急性髓系白血病患者的临床结局和共突变情况。
Int J Mol Sci. 2017 Jul 26;18(8):1618. doi: 10.3390/ijms18081618.
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Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment.靶向急性髓系白血病的免疫治疗概念:聚焦单克隆抗体、去甲基化药物及白血病微环境的作用
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A Case of AML Characterized by a Novel t(4;15)(q31;q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy.一例以新型t(4;15)(q31;q22)易位为特征的急性髓系白血病病例,该易位赋予对维甲酸类疗法的生长刺激反应。
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