青光眼和阿尔茨海默病中的视觉诱发电位

Visual Evoked Potentials in Glaucoma and Alzheimer's Disease.

作者信息

Cerri Elisa, Fabiani Carlotta, Criscuolo Chiara, Domenici Luciano

机构信息

Neuroscience Institute of the National Council of Research (CNR), Via G. Moruzzi 1, Pisa, 56100, Italy.

Department of Applied Clinical Sciences and Biotechnology (DISCAB), University of L'Aquila, Coppito 2, Via Vetoio 48, L'Aquila, Coppito, AQ 67100, Italy.

出版信息

Methods Mol Biol. 2018;1695:69-80. doi: 10.1007/978-1-4939-7407-8_7.

DOI:10.1007/978-1-4939-7407-8_7

PMID:29190019

Abstract

Visual responses to gratings alternating in contrast have been studied in humans and several mammalian species. Previous evidence from human patients and animal models of neurodegeneration has highlighted the importance to record simultaneously the pattern electroretinogram (P-ERG) and visual evoked cortical potentials (VEPs) to investigate retinal and post-retinal sites of neurodegeneration.In view of the increasing importance of research on experimental models of neurodegenerative diseases, we present here the parametric properties of visual evoked responses in animal models of glaucoma and Alzheimer's disease. Glaucoma and Alzheimer's disease (AD) are two distinct multifactorial neurodegenerative and progressive diseases, primarily affecting the elderly.

摘要

在人类和几种哺乳动物中，已经对视觉系统对对比度交替变化的光栅的反应进行了研究。先前来自人类患者和神经退行性疾病动物模型的证据强调了同时记录图形视网膜电图（P-ERG）和视觉诱发皮层电位（VEP）以研究神经退行性变的视网膜和视网膜后部位的重要性。鉴于神经退行性疾病实验模型研究的重要性日益增加，我们在此展示青光眼和阿尔茨海默病动物模型中视觉诱发反应的参数特性。青光眼和阿尔茨海默病（AD）是两种不同的多因素神经退行性和进行性疾病，主要影响老年人。