使用微电极阵列对视网膜功能输出的研究。

Investigation of the Functional Retinal Output Using Microelectrode Arrays.

作者信息

Zeck Günther

机构信息

Neurophysics, NMI at the University Tübingen, Markwiesenstrs. 55, Reutlingen, 72770, Germany.

出版信息

Methods Mol Biol. 2018;1695:81-88. doi: 10.1007/978-1-4939-7407-8_8.

DOI:10.1007/978-1-4939-7407-8_8

PMID:29190020

Abstract

Microelectrode array (MEA) recordings of the ex vivo flat-mounted retina enable the functional analysis of the retinal output. The electrical activity of a large portion of retinal ganglion cells (RGCs) is recorded simultaneously in response to various light stimuli. Analysis of the recorded time series of action potentials reveals physiological parameters such as firing rate, time latency, receptive field size, axonal conduction velocity. These parameters change during retinal diseases.

摘要

对离体平铺视网膜进行微电极阵列（MEA）记录能够对视网膜输出进行功能分析。在响应各种光刺激时，可同时记录大部分视网膜神经节细胞（RGC）的电活动。对记录的动作电位时间序列进行分析可揭示诸如放电率、时间潜伏期、感受野大小、轴突传导速度等生理参数。这些参数在视网膜疾病过程中会发生变化。