Pesola Arto J, Pekkonen Mika, Finni Taija
Duodecim. 2016;132(21):1964-71.
Increased epidemiological evidence over the past few years has shown excessive sitting to be a health risk even if recommendations for physical activity are fulfilled. Sitting is an independent health risk for two reasons: sitting and physical activity exhibit poor correlation, and an increase in physical activity does not contribute to all mechanisms underlying the health risks of sitting. During sitting, muscular passivity increases insulin resistance and influences the transport and oxidation of fatty acids in muscular tissue, and acute exercise is not sufficient to restore all changes. Accordingly, adequate everyday physical activity seems to be important for maintaining the signaling pathways affecting insulin sensitivity.
过去几年越来越多的流行病学证据表明，即使达到了身体活动的建议量，久坐仍会对健康构成风险。久坐是一种独立的健康风险，原因有两个：久坐与身体活动之间的相关性较差，而且增加身体活动并不能消除久坐对健康构成风险的所有潜在机制。在久坐期间，肌肉的被动状态会增加胰岛素抵抗，并影响肌肉组织中脂肪酸的转运和氧化，而急性运动不足以恢复所有这些变化。因此，充足的日常身体活动对于维持影响胰岛素敏感性的信号通路似乎很重要。
