Mundy M J, Wilson C G, Hardy J G
Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, UK.
Nucl Med Commun. 1989 Jan;10(1):45-50. doi: 10.1097/00006231-198901000-00007.
The effect of eating on the transit of radiolabelled particles through the small intestine has been monitored in eight healthy subjects dosed after an overnight fast. Each subject participated on three occasions and either remained fasting for 9 h after dosing or consumed a meal at 1.5 h or 4 h. The mean +/- 1 S.D. small intestinal transit time during the fasting study was 5.5 +/- 2.1 h and during the 1.5h and 4 h fed studies 4.8 +/- 2.9 h and 4.7 +/- 2.2 h, respectively. These times were not significantly different, nor were the rates of entry of the particles into the colon. These findings indicate that once in the small intestine the efficacy of orally administered pharmaceutical preparations is unlikely to be affected by eating.
在八名健康受试者中监测了进食对放射性标记颗粒在小肠中转运的影响，这些受试者在禁食一夜后给药。每位受试者参与三次，给药后要么禁食9小时，要么在1.5小时或4小时进食。禁食研究期间小肠平均转运时间±1标准差为5.5±2.1小时，进食1.5小时和4小时研究期间分别为4.8±2.9小时和4.7±2.2小时。这些时间无显著差异，颗粒进入结肠的速率也无显著差异。这些发现表明，口服药物制剂一旦进入小肠，其效果不太可能受到进食的影响。
