Department of Neonatology, Thomas Jefferson University, Nemours, Philadelphia, Pennsylvania.
Pediatrix Medical Group, Columbia, South Carolina.
Am J Perinatol. 2018 Jun;35(7):643-647. doi: 10.1055/s-0037-1608875. Epub 2017 Nov 30.
The objective was to determine if the presence of a nasogastric (NG) feeding tube is associated with increased gastroesophageal reflux (GER) and acid exposure in preterm infants.
This is a retrospective study on preterm infants [gestational age (GA) <37 weeks] who were evaluated by multichannel intraluminal impedance and pH monitoring (MII-pH) between October 2009 and March 2016. Infants were divided into two groups, NG tube present and no feeding tube. GER events per hour and the percent of time with pH <4 during a 24-hour period were then compared.
Eighty-three infants were included, 41 had an NG tube present and 42 did not. The group without an NG tube had significantly more reflux events per hour (2.3 ± 2.9 vs. 1.3 ± 0.8, < 0.05) even after adjusting for differences in birth weight, GA, corrected GA, and total fluid intake. There was no significant difference in acidic events per hour and acid exposure time between the two groups.
The presence of a 5-French NG tube is not associated with an increase in GER or acid exposure in preterm infants. In fact, it appears that infants fed through an NG tube have fewer episodes of GER.
本研究旨在确定鼻胃（NG）喂养管的存在是否与早产儿胃食管反流（GER）和酸暴露增加有关。
这是一项回顾性研究，纳入了 2009 年 10 月至 2016 年 3 月期间接受多通道腔内阻抗和 pH 监测（MII-pH）评估的早产儿[胎龄（GA）<37 周]。将婴儿分为两组，即存在 NG 管组和无喂养管组。然后比较每小时 GER 事件数和 24 小时内 pH 值<4 的时间百分比。
共纳入 83 名婴儿，其中 41 名存在 NG 管，42 名无喂养管。即使在调整了出生体重、GA、校正 GA 和总液体摄入量的差异后，无 NG 管组每小时的反流事件数仍显著更多（2.3±2.9 比 1.3±0.8，<0.05）。两组每小时酸暴露事件数和酸暴露时间无显著差异。
5-French NG 管的存在与早产儿 GER 或酸暴露的增加无关。事实上，通过 NG 管喂养的婴儿 GER 发作次数似乎更少。
