硫辛酸代谢与线粒体氧化还原调节。
Lipoic acid metabolism and mitochondrial redox regulation.
机构信息
From the Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
From the Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390
出版信息
J Biol Chem. 2018 May 18;293(20):7522-7530. doi: 10.1074/jbc.TM117.000259. Epub 2017 Nov 30.
Abstract
Lipoic acid is an essential cofactor for mitochondrial metabolism and is synthesized using intermediates from mitochondrial fatty-acid synthesis type II, -adenosylmethionine and iron-sulfur clusters. This cofactor is required for catalysis by multiple mitochondrial 2-ketoacid dehydrogenase complexes, including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and branched-chain ketoacid dehydrogenase. Lipoic acid also plays a critical role in stabilizing and regulating these multienzyme complexes. Many of these dehydrogenases are regulated by reactive oxygen species, mediated through the disulfide bond of the prosthetic lipoyl moiety. Collectively, its functions explain why lipoic acid is required for cell growth, mitochondrial activity, and coordination of fuel metabolism.
摘要
硫辛酸是线粒体代谢的必需辅酶，它使用来自线粒体脂肪酸合成 II 型、-腺苷甲硫氨酸和铁硫簇的中间产物合成。这种辅酶是多种线粒体 2-酮酸脱氢酶复合物（包括丙酮酸脱氢酶、α-酮戊二酸脱氢酶和支链酮酸脱氢酶）催化所必需的。硫辛酸在稳定和调节这些多酶复合物方面也起着关键作用。这些脱氢酶中的许多都受到活性氧的调节，这是通过辅基的二硫键介导的。总的来说，它的功能解释了为什么硫辛酸是细胞生长、线粒体活性和燃料代谢协调所必需的。
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