Hübsch P, Trattnig S, Traindl O, Wolszczuk W, Barton P, Seidl G, Kovarik J
Abteilung für Diagnostische Radiologie der II. Medizinischen Universitätsklinik Wien.
Radiologe. 1989 Jan;29(1):43-7.
Pathophysiological histological and radiological findings in renal osteodystrophy are described. Special emphasis is laid on secondary hyperparathyroidism. Preliminary results of the authors' investigations show a good correlation between radiological findings in the phalanges of the hand and the concentration of parathyroid hormone (PTH) in 14 patients. The concentration of the hormone in the blood was measured by a new "two-site" immunoradiometric assay, which is specific for the intact, biologically active hormone. Patients with high concentrations of PTH in the blood tended to have more severe radiological changes. In 4 patients for whom radiographs of the hands revealed no pathologic findings, normal PTH concentrations in the blood were measured by this method, whereas the conventional assay gave elevated hormone concentrations for the same patients. This is due to the lack of specificity of the conventional method for the intact, biologically active hormone. Nevertheless, further investigations are needed to confirm these findings.
本文描述了肾性骨营养不良的病理生理、组织学和放射学表现。特别强调了继发性甲状旁腺功能亢进。作者研究的初步结果显示，14例患者手部指骨的放射学表现与甲状旁腺激素（PTH）浓度之间存在良好的相关性。血液中该激素的浓度通过一种新的“双位点”免疫放射分析测定，该方法对完整的、具有生物活性的激素具有特异性。血液中PTH浓度高的患者往往有更严重的放射学改变。在4例手部X线片未发现病理改变的患者中，用该方法测得血液中PTH浓度正常，而传统检测方法对这些患者测得的激素浓度升高。这是由于传统方法对完整的、具有生物活性的激素缺乏特异性。然而，需要进一步研究来证实这些发现。
