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维持性血液透析患者的肾性骨营养不良:临床、放射学及生化特征的统计学研究

[Renal osteodystrophy in patients on maintenance hemodialysis: statistical study of clinical, radiological and biochemical features].

作者信息

Zwahlen A, Leski M, Burckhardt P, Assimacopoulos A, Garcia J, Szary L, Courvoisier B

出版信息

Schweiz Med Wochenschr. 1981 Jan 31;111(5):154-6.

PMID:7280647
Abstract

Sixty radiological, clinical and biochemical features were simultaneously recorded in a population of 46 patients on maintenance hemodialysis. Radiological signs of bone reabsorption (hands, acromio-clavicular and sacro-iliac joints) were demonstrated in 65% and were quantified as a radiological index of hyperparathyroidism. The index was correlated with the levels of parathormone and of alkaline phosphatase (p less than 0.01) and with the duration of renal failure (p less than 0.01), and inversely related to bone densitometry (p less than 0.05). Discriminant analysis confirmed the redundant value of parathormone and alkaline phosphatases in predicting bone lesions. Factorial analysis showed the existence of 12 classes of patients statistically close to one another. These results demonstrate the heterogeneity of renal osteodystrophy.

摘要

在46例维持性血液透析患者群体中,同时记录了60项放射学、临床和生化特征。65%的患者出现了骨吸收的放射学征象(手部、肩锁关节和骶髂关节),并将其量化为甲状旁腺功能亢进的放射学指标。该指标与甲状旁腺激素水平、碱性磷酸酶水平相关(p<0.01),与肾衰竭持续时间相关(p<0.01),与骨密度测定呈负相关(p<0.05)。判别分析证实了甲状旁腺激素和碱性磷酸酶在预测骨病变方面的冗余价值。因子分析显示存在12类统计学上彼此接近的患者。这些结果证明了肾性骨营养不良的异质性。

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