Baste Subia Maria N, Digoy Paul, Hum Martina, Yu Zhongxin, Conrad Rachel
Department of Pathology and Laboratory Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, U.S.A.
Department of Surgery, Oklahoma State University Center for Health Sciences, Oklahoma City, Oklahoma, U.S.A.
Laryngoscope. 2018 Feb;128(2):E78-E82. doi: 10.1002/lary.27020. Epub 2017 Nov 29.
Spindle epithelial tumor with thymus-like elements (SETTLE) is a rare and morphologically unique biphasic pediatric thyroid tumor of low malignant potential. There are less than 50 cases reported in the literature and few reported metastases. Despite the common usage of needle aspiration for thyroid and lymph node evaluation, cytologic descriptions of SETTLE are rare and tend to focus on a hypercellular biphasic appearance. We report aspirate findings of early cystic lymph node metastases in a 14-year-old girl, showing abundant matrix and low cellularity. We propose that the lack of recognition of this abundant matrix and cystic ultrasound appearance (as well as rarity of this tumor) may account for the low number of cytologic descriptions in the literature. Improved recognition may lead to increased usefulness of aspiration in the diagnosis and follow-up of SETTLE. Laryngoscope, 128:E78-E82, 2018.
伴有胸腺样成分的梭形上皮肿瘤（SETTLE）是一种罕见的、形态独特的、具有低恶性潜能的小儿双相性甲状腺肿瘤。文献报道的病例不足50例，且鲜有转移的报道。尽管针吸活检常用于甲状腺和淋巴结评估，但关于SETTLE的细胞学描述却很少，且往往集中在细胞增多的双相外观上。我们报告了一名14岁女孩早期囊性淋巴结转移的针吸活检结果，显示基质丰富且细胞数量少。我们认为，对这种丰富基质和囊性超声表现的认识不足（以及该肿瘤的罕见性）可能是文献中细胞学描述数量较少的原因。提高认识可能会提高针吸活检在SETTLE诊断和随访中的实用性。《喉镜》，2018年，第128卷：E78-E82页
