颗粒细胞基底细胞癌：一例报告。

Granular cell basal cell carcinoma: A case report.

作者信息

Ma Xinyi, Wang Guihua, Kuwadekar Aditya, Zhao Min, Hu Weili, Wu Yeqin, Yi Zhongliang, Xu Xianen, Xu Li

机构信息

Department of Pathology, Hang Zhou Dian Medical Laboratory, Hang Zhou, ZheJiang Province, P. R. China.

Department of Pathology, Affiliated Hospital of Hang Zhou Normal University, Hang Zhou, Zhejiang Province, P. R. China.

出版信息

J Cutan Pathol. 2018 Mar;45(3):223-225. doi: 10.1111/cup.13087. Epub 2018 Jan 3.

DOI:10.1111/cup.13087

PMID:29193208

Abstract

Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC. Our review of the literature revealed only 17 previously identified cases. We report the case of a 47-year-old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high-power fields, with a Ki-67 proliferative index of ~5%. Immunohistochemically, the granular cells showed strong and diffuse positivity for Ber-EP4, pan-cytokeratin, AE1/AE3, CK5/6 and p63 and focal positivity for lysozyme, CD68 (clone KP1) and Bcl-2.

摘要

颗粒细胞基底细胞癌（BCC）是基底细胞癌一种罕见的组织病理学变体。我们对文献的回顾显示，此前仅发现17例病例。我们报告了一名47岁男性的病例，该患者右上唇出现溃疡，随后进行了切除。组织病理学检查显示，肿瘤仅由颗粒细胞组成，这些颗粒细胞含有大量嗜酸性细胞质圆形包涵体。每10个高倍视野中的有丝分裂象为8至15个，Ki-67增殖指数约为5%。免疫组织化学检查显示，颗粒细胞对Ber-EP4、泛细胞角蛋白、AE1/AE3、CK5/6和p63呈强弥漫性阳性，对溶菌酶、CD68（克隆KP1）和Bcl-2呈局灶性阳性。